AI for Quality, CMC & Regulatory Operations

The risk isn't in one framework. It's in the overlap.

The intelligence layer for regulated records. Clinplex reads across 150+ frameworks at once — surfacing the gaps, cross-framework risk and draft-ready fixes your siloed systems can't see.

Team experience includes · life sciences, federal health & enterprise software
Live
Overlap found
2.4s · cross-framework scan
CAPA draft prepared
QA Ops · due 7 days
Mapped against 150+ regulatory frameworks
FDA 21 CFR 211ICH Q7EU GMP Annex 11ISO 13485ICH E6(R3)21 CFR Part 11MDSAPICH Q10eCTD v4.021 CFR 58ICH M4EU GVPUSP <1058> FDA 21 CFR 211ICH Q7EU GMP Annex 11ISO 13485ICH E6(R3)21 CFR Part 11MDSAPICH Q10eCTD v4.021 CFR 58ICH M4EU GVPUSP <1058>
§ The Category

Not another QMS.
The intelligence layer over it.

Eleven systems can each hold part of the evidence. The regulatory risk often sits in the relationship between them. Clinplex reads across that boundary.

Your records are already there. The intelligence isn’t.

The QMS contains the deviation. The LIMS contains the result. Validation contains the qualified state. Clinplex evaluates whether the combined evidence supports the same regulatory conclusion.

Clinplex is the AI regulatory intelligence layer that augments your QMS. The QMS is the system of record. Clinplex is the intelligence layer the QMS was never designed to provide.

Reads across, not by framework
150+ frameworks evaluated in parallel — overlaps surface instead of hiding in separate libraries.
Read-only by default
Connects to Veeva Vault, MasterControl and ValGenesis. Never writes to your validated systems.
Cascading, with an owner
Every finding carries its linked records, a citation, an owner and a due date — not four reports stitched together.
Integration model
Read-only
Intelligence Layer
Gap detection Risk ranking Audit ready
READ-ONLY BY DEFAULT
QMS supported
Quality Management
MasterControl · Veeva QualityDocs · Sparta
LIMS supported
Lab & Sample Records
LabWare · STARLIMS · LabVantage · Benchling
VALIDATION supported
CSV & Process Validation
ValGenesis · Kneat · Veeva Validation Mgmt
+ eCTD · SAP · SharePoint · Veeva RIM
One cascading view.
§ Four Pillars · Molecule to Market

What that intelligence
actually does.

Four capabilities across the full product lifecycle — molecule to market.

01 · CONTINUOUS

Continuous gap detection

Reads SOPs, batch records, OOS results and eCTD modules — re-evaluating records as relevant evidence changes — not waiting for the next audit.

  • Cross-framework scan in seconds
  • Citations to specific clauses
  • Change-aware re-scoring
02 · PRIORITIZED

Risk prioritization from enforcement patterns

Findings ranked against published enforcement history — 483 observations, warning letters, inspection outcomes — so attention goes where observations actually happen.

  • Site & product heatmaps
  • Deviation → systemic CAPA signals
  • Enforcement-pattern ranking
03 · OPERATIVE

Operational intelligence

Cascades findings across connected evidence and routes ownership and escalation inside Clinplex, while customer systems remain read-only.

  • Clinplex workflow ownership
  • Cross-system traceability
  • One queue, four functions
04 · AUDIT

Audit readiness, on demand

Every detection, disposition and closure carries a timestamped, attributable evidence trail designed to support Part 11 controls — review-ready dossiers assemble as a byproduct of daily work.

  • Part 11-supporting audit trail
  • FDA / EMA / MDSAP packages
  • Evidence assembled continuously
i · Discovery
Preclinical & GLP
21 CFR 58 · ICH M3
ii · Clinical
GCP & IND/CTA
ICH E6 · 21 CFR 312
iii · CMC
Manufacturing & Quality
21 CFR 211 · ICH Q7
iv · Submission
eCTD & Approval
ICH M4 · eCTD v4.0
All four pillars · across the entire lifecycle · molecule to market
§ Building Next · Regulator Divergence

The same document.
Four regulators. Four readings.

Multi-region sponsors answer to FDA, EMA, MHRA and PMDA at once — and the same evidence may create different expectations or inspection risk across authorities. That requires jurisdiction-aware reasoning across the same evidence, not simply another place to store it.

In development
"Same evidence. Different regulatory expectations."
The divergence view starts deliberately narrow — two regulators, one framework family — because a wrong divergence call is worse than none. Built on the same clause-cited framework mapping that powers every Clinplex finding today.
§ Two Sides of the Inspection

Same intelligence.
Both sides of the table.

The overlap that creates regulatory exposure for a sponsor is the same evidence a reviewer must evaluate. One engine reads it — for whoever is holding the file.

For industry

Find the 483 before the inspector does.

Quality, regulatory and clinical operations teams surface exposure across their own records — and close it before an audit ever opens.

Sponsors QA / RA Clinical Dev / Ops CMOs & CROs Med device
01
Pre-inspection gap scan
Reads across QMS, LIMS and validation to surface cross-record inconsistencies before the inspector sees them.
02
CAPA draft prepared and assigned
Every finding arrives with a source citation, linked records, an accountable owner and due date inside Clinplex.
03
Continuous inspection readiness
Readiness becomes a standing operating state rather than an end-game preparation project. Evidence assembles continuously as records are reviewed, linked and closed.
For regulators & reviewers

Evaluate cross-framework regulatory exposure in hours, not weeks.

Clinplex gives agencies, notified bodies and auditors a consistent way to evaluate a filing against applicable requirements, with every finding tied to its governing source and underlying record.

Agencies Notified bodies Inspectors Auditors
01
Overlap across the full filing
Cross-framework gaps surface in one pass — no toggling between eleven separate libraries.
02
Consistent, defensible scoring
Every reviewer sees the same ranked risk, so judgment calls start from a shared baseline.
03
Every finding carries its source
Each flag links to the governing clause and the exact record behind it.
§ Why Clinplex, Not an LLM

A general LLM can read the document.
Clinplex knows what must hold together.

The model is one component. Around it sits the regulated system a chatbot doesn't have.

Controlled regulatory knowledge
Curated requirements with jurisdiction, version, effective date and applicability.
Cross-record evidence graph
The relationships between SOP → deviation → CAPA → validation → submission, evaluated as one chain.
Regulatory reasoning schema
Every output is structured: finding, severity, requirement, rationale, linked impact, remediation.
Reproducibility and evaluation
Benchmarked outputs, drift testing, false-positive and false-negative monitoring.
Governed human workflow
Qualified review and approval stay accountable; the evidence trail is retained.

The foundation model can change. The governed regulatory system around it is the product.

§ The Proof

What changes when overlap
becomes visible.

Evaluated on a 1,035-document regulated corpus, including a blinded, SME-reviewed 312-document subset — presented at the DIA 2026 Global Annual Meeting.

96%

Gap-detection accuracy

Measured against SME-panel ground truth.

3.0×

More gaps surfaced

12.3 gaps per SOP vs 4.1 under single-framework review.

73%

Less assessment time

Reduction in cross-framework assessment time.

98%

Critical-tier sensitivity

Critical findings detected relative to SME-panel ground truth.

2.4s median scan on the benchmark corpus · 150+ frameworks mapped · timestamped evidence trail
"
The signal behind your next 483 may already be in your QMS. The question is whether you see it before the inspector does.
— The Clinplex thesis

See it on your
own records.

Send a closed deviation, its CAPA and the governing SOP. Mutual NDA goes out the same day; findings come back within 48 hours. Redacted records are fine. Free.