Complete Guide to Drug Lifecycle Regulatory Compliance | Clinplex AI
Every pharmaceutical product moves through a regulated lifecycle — from the first preclinical study to post-market surveillance. This guide maps the complete regulatory landscape across all five domains: GLP, GCP, GMP, eCTD submissions, and pharmacovigilance. Frameworks, documentation requirements, and where compliance gaps most commonly occur.Cross-Domain Regulatory Intelligence: Why the Most Dangerous Compliance Gaps Span Multiple Departments — Clinplex AI
The most expensive compliance failures aren't caused by a single department missing a single requirement. They're caused by signals spanning multiple regulatory domains — manufacturing deviations impacting submissions, PV signals requiring clinical protocol changes, GLP findings invalidating IND applications. Cross-domain intelligence detects patterns that siloed tools miss.AI-Powered GLP Compliance: From Preclinical Documentation to IND-Ready Submissions — Clinplex AI
Every IND application depends on nonclinical safety data generated under GLP. AI evaluates preclinical documentation against 21 CFR Part 58, ICH M3(R2), and Part 11 data integrity standards — scoring GLP study report adequacy, IND-enabling study readiness, and identifying where preclinical gaps create downstream problems in clinical programs.AI-Powered Pharmacovigilance Compliance: PSUR, PBRER & Signal Detection | Clinplex AI
Pharmacovigilance is where compliance failures have the most direct patient safety consequences. AI evaluates PV documentation against ICH E2A–E2F, 21 CFR 314.80, and EU GVP modules — scoring PSUR/PBRER adequacy, risk management plan completeness, and adverse event investigation quality. Cross-domain intelligence connects PV signals to labeling, clinical, and manufacturing actions.AI-Powered Submission Readiness: How Regulatory Intelligence Prevents Complete Response Letters — Clinplex AI
Complete Response Letters trace to documentation deficiencies that existed months before filing. AI-powered submission readiness scoring evaluates eCTD Modules 1–5 against ICH M4 content requirements, verifies cross-module consistency, and quantifies NDA/BLA readiness — identifying gaps that trigger CRLs before the submission is filed.How AI Is Transforming GCP Compliance and Clinical Trial Regulatory Intelligence — Clinplex AI
Clinical trial compliance generates thousands of regulatory documents across sites and jurisdictions. AI regulatory intelligence evaluates every clinical document against ICH E6(R2), 21 CFR 312, and FDA guidance — continuously, not just during periodic GCP audits. Cross-domain connections link clinical findings to manufacturing, submission, and pharmacovigilance implications.